Reactive oxygen's role in metastasis

Researchers at the Burnham Institute for Medical Research (Burnham) have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumour metastasis. Sara Courtneidge, professor and director of the Tumour Microenvironment Program at Burnham's NCI-designated Cancer Centre, and colleagues have found that inhibiting reactive oxygen reduces invadopodia formation and limits cancer cell invasion. The study was published on 15 September in the journal Science Signaling...

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