Study resolves controversy surrounding tumor suppressor gene's role in pluripotent ESCs
Monday, June 1, 2020 - 09:31
in Biology & Nature
The gene p53 is extremely important in cell biology and, hence, the world of cell replacement therapy. Its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the "tumor suppressor gene." However, previous efforts to determine whether p53 is behind programmed cellular death (apoptosis) induced by DNA damage in pluripotent embryonic stem cells (ESCs) produced conflicting results. Initial studies said that it was not; later studies concluded that it was.