Enhanced osteogenic activity of pre-osteoblasts on surface-modified 3-D printed scaffolds
Thursday, December 13, 2018 - 09:50
in Physics & Chemistry
Materials such as poly(ε-caprolactone) are used as scaffolds in bone tissue engineering, but their inherent hydrophobicity and surface smoothness can impair cell attachment, proliferation and differentiation in the lab, or after implantation in vivo. Surface modifications including chemical alterations or the immobilization of biologically active molecules on materials can overcome the intrinsic hydrophobicity of poly(ε-caprolactone) (PCL). In a recent study, bioengineers Yasaman Zamani and her colleagues investigated a chemically modified, 3-D printed PCL material surface immobilized with RGD peptide (R: arginine, G: glycine, D: aspartic acid). The results of the study are published on Biomedical Materials, IOP Publishing.