'Acidic patch' regulates access to genetic information

Tuesday, August 15, 2017 - 02:02 in Biology & Nature

Chromatin remodelers—protein machines that pack and unpack chromatin, the tightly wound DNA-protein complex in cell nuclei—are essential and powerful regulators for critical cellular processes, such as replication, recombination and gene transcription and repression. In a new study published Aug. 2 in the journal Nature, a team led by researchers from Princeton University unravels more details on how a class of ATP-dependent chromatin remodelers, called ISWI, regulate access to genetic information.

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