Click and declick of amine and thiol coupling reaction

Monday, September 26, 2016 - 08:31 in Biology & Nature

(Phys.org)—A group of researchers from the University of Texas have developed a sequential, two-step amine and thiol coupling reaction via click chemistry using a derivative of Meldrum's acid. This reaction is reversible using what the authors term a "declick" reaction, and the original amine and thiol can be retrieved. Their work appears in Nature Chemistry.

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