Researchers use viral particles to trap intact mammalian protein complexes

Friday, April 29, 2016 - 08:10 in Biology & Nature

Belgian scientists from VIB and UGent developed Virotrap, a viral particle sorting approach for purifying protein complexes under native conditions. This method catches a bait protein together with its associated protein partners in virus-like particles that are budded from human cells. Like this, cell lysis is not needed and protein complexes are preserved during purification. The development and application of this pioneering technique are described in a paper published this week in Nature Communications.

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