Team engineers designer proteins that control enzyme activity

Scientists from the University of Chicago have developed a novel approach to control the activity of enzymes through the use of synthetic, antibody-like proteins known as monobodies. A team led by Shohei Koide, PhD, professor of biochemistry and molecular biophysics, was able to change the specificity of an enzyme, widely used in the food industry, without altering the enzyme itself - establishing a new route for enzyme engineering and demonstrating the versatility of these synthetic proteins. The findings, detailed online in Nature Chemical Biology on Aug. 31, 2015, have widespread implications for a broad range of industrial, scientific and medical applications in which enzymes are used.

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