A breakthrough in nanotoxicology

Whereas resistance to antibiotics complicates certain treatments, antimicrobial silver nanoparticles (AgNP) are gaining popularity for medical use. These particles are toxic for certain bacteria, but what about for humans? Researchers at INRS-Institut Armand-Frappier Research Centre have taken a step toward understanding the cellular and molecular mechanisms that affect these particles. In an article published in The Journal of Biological Chemistry, Denis Girard's team established for the first time that AgNP induce stress in the endoplasmic reticulum (ER), which is one of the signs of nanotoxicity.

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