Collagen remodeling after micro-ablative fractional laser resurfacing can be monitored by two-photon microscopy

Many people in the Western World consider it as a social need to hide the effects of aging. For this purpose, different cutaneous rejuvenation treatments have been developed, including a laser-based technique, known as laser resurfacing. Skin irradiation with high-power pulsed laser light induces a thermal shock which stimulates fibroblasts to produce new collagen. This is arranged in a more ordered fashion with respect to the old one, thus reducing wrinkles. To avoid long wound healing time and related risks, an improved method has been developed: micro-ablative fractional laser resurfacing ablates skin only on raster scanned points while the light energy dose deposited is still enough to activate fibroblasts and new collagen production.

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