Wiping the slate clean: Erasing cellular memory and resetting human stem cells

Babraham Institute scientists, in collaboration with colleagues at the Cambridge Stem Cell Institute and the European Bioinformatics Institute, have published findings today in the journal Cell giving hope that researchers will be able to generate base-state, naïve human stem cells for future medical applications. The study demonstrates that human stem cells can be reverted back to a base state, losing characteristics that mark them as belonging to a specific cell lineage and instead regaining the identify of a non-specialised cells with unrestricted potential (pluripotency) to develop into any cell type.

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