Scientists manipulate the Set2 pathway to show how genes are faithfully copied

The first step in gene expression is the exact copying of a segment of DNA by the enzyme known as RNA polymerase II, or pol II, into a mirror image RNA. Scientists recognize that pol II does not transcribe RNA via a smooth glide down the DNA highway but instead encounters an obstacle course of DNA tightly wound around barrier proteins called histones. Those proteins must be shoved aside for pol II to trundle through.

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