(Phys.org) -- In a tale worthy of Sherlock Holmes, scientists in the School of Chemistry at the University of Bristol, UK have solved a biochemical mystery that had previously proven elusive for 70 years: How the fungus Talaromyces stipitatus produces stipitatic acid (6), which is a tropolone, one of an atypical group of fungal natural products – that is, small molecules produced by genetically encoded pathways – with a seven-carbon ring. (Most natural products, such as cholesterol or phenylalanine, have five or six carbons in rings.) The researchers used a two-part biosynthetic approach – gene deletion and alternate genetic expression – to investigate the molecular pathway in question.
- Gene find could lead to healthier food, better biofuel productionMon, 22 Nov 2010, 17:03:58 EST
- Researchers uncover molecular pathway through which common yeast becomes fungal pathogenSat, 17 Mar 2012, 15:20:57 EDT
- Biosynthetics production with detoursFri, 31 Oct 2008, 14:11:23 EDT
- Tiny molecules protect from the dangers of sexSun, 14 Nov 2010, 20:50:48 EST
- MU researchers find missing link in plant defense against fungal disease Tue, 19 Apr 2011, 14:23:41 EDT