Sweating the small stuff: Early adversity, prior depression linked to high sensitivity to stress

We all know people who are able to roll with life's punches, while for others, every misfortune is a jab straight to the gut. Research examining this issue has found that although most people require significant adversity to become depressed — the death of a loved one, say, or getting fired — roughly 30 percent of people with first-time depression and 60 percent of people with a history of depression develop the disorder following relatively minor misfortunes. But no one knew why.

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