Breast cancer stem cells (CSCs), the aggressive cells thought to be resistant to current anti-cancer therapies and which promote metastasis, are stimulated by estrogen via a pathway that mirrors normal stem cell development. Disrupting the pathway, researchers were able to halt the expansion of breast CSCs, a finding that suggests a new drug therapy target. The study, done in mice, is published in the Proceedings of the National Academy of Sciences (PNAS) Early Edition this week.
- Discovery halts breast cancer stem cellsTue, 23 Nov 2010, 11:02:43 EST
- Therapy may block expansion of breast cancer cellsWed, 5 Nov 2008, 17:08:30 EST
- Researchers find driver of breast cancer stem cell metastasis Thu, 26 Jul 2012, 9:06:48 EDT
- U-M researchers link pathway to breast cancer stem cellsMon, 1 Jun 2009, 20:22:51 EDT
- Estrogen reduces aggression in breast cancerMon, 14 Feb 2011, 10:35:50 EST