Recombination hotspot stacks the DNA deck in finding a new diabetes susceptibility gene

Wednesday, November 3, 2010 - 17:30 in Biology & Nature

The autoimmune disease type 1 diabetes (T1D), also known as juvenile diabetes, is diagnosed in approximately 70,000 children worldwide per year. Genetics is increasingly being recognized as playing a significant role in susceptibility to the disorder, but outside a handful of genes, a clear understanding of the genetic architecture that underlies T1D has remained elusive. In a study published online today in Genome Research, scientists have identified a novel gene associated with diabetes in mice that is revealing new clues about genomic mechanisms that could underlie T1D susceptibility.

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