Defective signaling pathway leads to vascular malformations in the brain

A disrupted signaling pathway in endothelial cells, which line the insides of blood vessels, leads to cavernomas, vascular malformations in the brain which are often dangerous. This has been published by a research team of the Medical Faculty Mannheim of Heidelberg University and the German Cancer Research Center. The investigators have found the cause of one of the most common human malformations and point out that cavernomas might be treated by drugs which inhibit vascular growth.

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