Rethinking guidelines for treating high blood pressure: Variability is a risk factor too

Hypertension is the most prevalent treatable risk factor for stroke. One in two adults are affected by it, and the risk of being hypertensive during a lifetime is about 90%. Despite this, the underlying mechanisms by which raised blood pressure can cause cardiovascular disease are poorly understood. Clinical guidelines for the diagnosis and treatment of hypertension focus heavily on mean systolic blood pressure.

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