The Key that Fits: New Technique To Trace Disease-Related Agents

Friday, March 5, 2010 - 10:21 in Health & Medicine

(PhysOrg.com) -- In the development of new drugs, photoaffinity labels (PALs) are a versatile tool to investigate the interaction between a receptor and a drug or a ligand. Researchers working with Stephanie Grond at the University of Tübingen and Paultheo von Zezschwitz at the University of Marburg have now developed a new class of PALs that can be attached to the ligand in a single step, thus causing less modification of its structure, as they report in the European Journal of Organic Chemistry. The group has tested the new labels on an enzyme that is linked to osteoporosis and cancer.

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