Brain protein may be a target for fast-acting antidepressants

(PhysOrg.com) -- It takes weeks or months for the effect of most antidepressants to kick in, time that can feel like an eternity to those who need the drugs the most. But new research suggests that a protein called p11, previously shown to play a role in a person`s susceptibility to depression, activates a serotonin receptor in the brain known for producing a rapid antidepressant response. If scientists could develop drugs to target this receptor, they might produce an effect in as little as two days.

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