Anything but modest: The mouse continues to contribute to humankind

"Big things come in small packages," the saying goes, and it couldn't be more true when discussing the mouse. This little creature has become a crucial part of human history through its contributions in understanding human genetics and disease. In a review published in Disease Models & Mechanisms (DMM) genetics researchers from Yale University School of Medicine and Fudan University School of Life Sciences discuss the history and future of mice as a model organism. They predict that the next frontiers in mouse genetics - such as creating mice expressing human genes to create "humanized" mice - will continue to provide scientists with new tools to not only decipher clinical mysteries, but also to test novel therapies and cures.

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