New Version of DNA Editing System Corrects Underlying Defects in RNA-based Diseases

Thursday, August 10, 2017 - 13:02 in Biology & Nature

Until recently, CRISPR-Cas9 gene editing could only be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes that lead to microsatellite repeat expansion diseases, which include a type of ALS and Huntington's disease.

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