Research Helps Explain How B Cell Metabolism Is Controlled
Monday, January 23, 2017 - 11:51
in Health & Medicine
New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) addresses the lack of knowledge about how B cell metabolism adapts to each of their various environments-- development in the bone marrow, proliferation and hypermutation in the lymph nodes and spleen and circulation in the blood. New findings show that the protein GSK3 acts as a metabolic sensor, or checkpoint, that promotes the survival of circulating B cells while limiting growth and proliferation of B cells in germinal centers.