Rewiring Metabolism Slows Colorectal Cancer Growth

A University of Utah-led study reports that cancers select against a protein complex called the mitochondrial pyruvate carrier (MPC), and re-introduction of MPC in colon cancer cells impairs several properties of cancer, including growth. The research, which appears online on Oct. 30 in Molecular Cell, implicates changes in a key step in metabolism - the way cellular fuel is utilized - as an important driver of colon cancer that is also likely to be important in many other cancer settings.

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