Researchers able to determine the effects of genes and environment in 560 common conditions
When it comes to disease and health, which is more powerful — ZIP code or genetic code? The degree to which nature and nurture affect disease and health remains one of the eternal — and still unanswerable — questions in medicine. Now a team of investigators from Harvard Medical School (HMS) and the University of Queensland in Australia have tackled this question in a decidedly novel way. In what the researchers describe as a coup for big data and a scientific first, the team has used a massive insurance database of nearly 45 million people in the U.S., including thousands of twin pairs to determine the effects of genes and environment in 560 common conditions. The diseases analyzed span 23 categories, ranging from cardiovascular illness and neuromuscular diseases to skeletal conditions. The work, published Jan. 14 in Nature Genetics, is thought to be the largest assessment of U.S. twins to date, the researchers said. It...