Which neuron is more mature? Single cell transcriptome knows!
Monday, March 14, 2016 - 18:00
in Biology & Nature
This is the cover of Protein & Cell. The human brain is extremely complex, containing billions of neurons forming trillions of synapses where thoughts, behavior and emotion arise. However, when an individual is performing a particular task, not many but only a few neural circuits are in action. The enormous cellular heterogeneity of the brain structure has made dissections of the molecular basis for neural circuitry function particularly challenging, because previous studies on genetic and epigenetic profiling using a block of brain tissues simply do not have the sufficient precision and accuracy to correspond to the activities of a few activated circuitries in the brain.