Broad, MIT scientists overcome key CRISPR-Cas9 genome editing hurdle
Tuesday, December 1, 2015 - 20:30
in Biology & Nature
Slaymaker and Gao et al. used structural knowledge of Cas9 to guide engineering of a highly specific genome editing tool. Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have engineered changes to the revolutionary CRISPR-Cas9 genome editing system that significantly cut down on "off-target" editing errors. The refined technique addresses one of the major technical issues in the use of genome editing.