Circadian genes go to sleep every day at the periphery of the nucleus

Dr. Anita Göndör and her colleagues at Karolinska Institutet show that circadian genes 'take a nap' everyday at the periphery of the nucleus. Mobility between different physical environments in the cell nucleus regulates the daily oscillations in the activity of genes that are controlled by the internal biological clock, according to a study that is published in the journal Molecular Cell. Eventually, these findings may lead to novel therapeutic strategies for the treatment of diseases linked with disrupted circadian rhythm.

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