New gene therapy method provides specific, safe control of therapeutic transgenes
Monday, July 13, 2015 - 18:30
in Biology & Nature
Korean researchers have described a novel control system to regulate the expression of a therapeutic transgene by targeting the passenger strand of a microRNA (miR-122) linked to the transgene. The researchers report that a control system based on targeting the passenger strand of miR-122 rather than the guide strand can regulate expression of an exogenous, therapeutic gene, while not affecting the expression of endogenous genes, in an article in Nucleic Acid Therapeutics. The article is available free on the Nucleic Acid Therapeutics website until August 13, 2015.