Tumor genome sequencing shows the most frequently altered gene in bladder cancer: Telomerase reverse transcriptase

Monday, April 20, 2015 - 19:30 in Health & Medicine

In results presented today at the American Association for Cancer Research (AACR) Annual Meeting 2015, a collaborative study by the University of Colorado Cancer Center and the National Cancer Institute (NCI) reports that the TERT gene promoter was altered in 69 percent of 54 cases of bladder cancer due to variants that occur after birth (called "somatic") and in 56 percent of bladder cancers due to inherited variants (called "germline"). The study shows these TERT alterations frequently co-occur with alterations in recently identified bladder cancer genes such as the stromal antigen 2 (STAG2), and the lysine-specific demethylase 6A (KDM6A).

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