Splice variants reveal connections among autism genes

Friday, April 11, 2014 - 19:16 in Biology & Nature

Splicing variants (red) of autism genes were cloned from the brain and screened for interactions. The image on the right represents the network of interactions. A team of researchers from the University of California, San Diego School of Medicine and the Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute has uncovered a new aspect of autism, revealing that proteins involved in autism interact with many more partners than previously known. These interactions had not been detected earlier because they involve alternatively spliced forms of autism genes found in the brain.

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