... be used to analyze protein complexes. An additional featured article details the generation of viral vectors for gene transfer. "Systematic Monitoring of Protein Complex Composition and Abundance by ...
A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according ...
... didn't work, they did work when the genes were arranged in a specific order on a single vector. The same arrangement worked when the genes were incorporated into a plasmid.
To determine if the ...
... pluripotent stem (iPS) cells completely free of viral vectors and exotic genes. By reprogramming skin ... generating iPS cells without inserting viral vectors into the cells' genetic material is a major ...
... , cartilage, fat, and muscle. Genes were inserted into the hematopoietic stem cells using one of two viral vectors — either a retrovirus or a lentivirus — before they were transplanted into the mice, ...
... monkey model by introducing altered forms of the Huntington gene into monkey eggs using a viral vector. The eggs were fertilized and the resulting embryos were introduced into surrogate mothers, ...
... remained infectious. While the experiment only involved one type of protein and two types of viral vectors, Salmons says the technique could be expanded and used to apply “paint” made up of other ...
... approaches in the current HIV vaccine field rely on viral vector-based delivery systems, an approach that produced disappointing results in a recent efficacy trial. Drs. Markham ...
... key genes for the biological clock, BMAL1, was disabled. They next placed the gene for BMAL1 into a viral vector which enabled them to restore a functional biological clock to only one spot in the ...
... fatal. Synthetic vectors, which use synthetic molecules to package genes, are generally safer than viral vectors, Geng said. The downside is that they're not nearly as efficient. For millions of years ...
... , M.D., Ph.D., of Thomas Jefferson University in Philadelphia and colleagues immunized mice with a viral vector that expressed guanylyl cyclase C protein, which is normally only expressed in the ...
... including anxiety, depression and infertility.
To study the importance of CRF, the research team used a viral vector to increase the production of CRF in the amygdala of female rats.
"In our study ...
... and microbiology and director of UF's Powell Gene Therapy Center, which manufactured the viral vectors used in the study. "Improvements in someone's medical condition are ultimately what we are after ...
... not significantly reduced tumor progression. One problem has been that patients' immune systems target the viral vectors used to deliver cancer-eliminating genes. Another issue has been inefficient ...
... of type 1 diabetes mellitus. Chitosan nanoparticle is a kind of non-viral vector. A research group in China investigated the gene therapy for type 1 diabetes mellitus in rats by ...
