Science news articles about 'tumor suppressor p53'

... Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new ... expression reduced p53 levels. Loss of Trim24 expression in a breast cancer cell line ...

... for novel inhibitors that stop or slow cancer tumor growth. In fact, Budanov obtained results ... rise to cancer, are eliminated. The major tumor suppressor p53 can either inhibit cell proliferation ...

... study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become ...

Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, ... copies of Mdm2. Mice with the double-mutant p53 that also had no Mdm2 died sooner and developed ...

... off acetyl groups, which can inactivate the tumor suppressor p53. Yuan et al. determined ... hastening its breakdown. To test SIRT1's effects on tumor growth, the researchers implanted cancerous cells ...

... door to understanding a possible cause of these brain tumors," said co-senior author Melissa Bondy ... 9, regulates p14, which activates the tumor-suppressor p53. It also regulates cyclin-dependent kinases ...

... anti-cancer therapies. As a powerful tumor suppressor, p53 turns on genes that either halt ... catastrophic DNA damage these low levels of p53 were enough to suppress tumorigenesis." But in order to put ...

... C-NHEJ-deficient mice. Further, on a tumor suppressor p53-deficient background, XLF-deficient mice ... likely to develop non-immune cell tumors. The findings demonstrate that although the XLF-deficient ...

... her lab, found that apigenin localizes tumor suppressor p53, a protein, in the cell nucleus – a necessary ... growth and cause cell death. In this way, p53 ensures that cells with damaged DNA are killed ...

... three separate brain regions of mice lacking one copy of the gene encoding the tumor suppressor p53: the hippocampus, which is involved in learning and memory; the subventricular zone, which lines ...

... . Watnick and colleagues also demonstrated that prosaposin stimulates activity of the well-known tumor suppressor p53 in the connective tissue (stroma) surrounding the tumor. This in turn stimulated ...

By activating the tumor suppressor p53, a new drug may slow the malignancy, a study in mice shows