Science news articles about 'protein domain'Carnegie Mellon scientists unveil new tool to understand evolution of multi-domain genes
... applied genes encode multi-domain proteins. Domains are sequence fragments that encode the basic ... well in verifying the ancestral patterns of multi-domain gene evolution for these families, much better ... Scientists characterize protein structure of environmentally friendly bacteria
... the U.S. Department of Energy's Argonne National Laboratory have determined the structure of a key protein domain in a bacterium that could help with bioremediation of uranium-contaminated land sites.Getting wise to the influenza virus' tricks
... publish a high-resolution image of a key protein domain whose function is to allow the virus ... messenger RNAs (mRNAs) to direct the cell's protein-synthesis machinery to the starting point. The viral ... Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
... for transforming growth factor ƒÒ and urokinase plasminogen activator. "There are quite a few other human proteins with similar predicted structures whose function is not yet known," says Lemmon. "We ... Protein linked to Alzheimer's disease also has role in HIV progression
... . Yet this seemingly small sequence difference has profound implications for the structure and function of the protein. ApoE4 has an extra intramolecular bond that results in a more compact structure, ... Tracking prions
... two different forms of a prion-forming protein domain by means of NMR spectroscopy. In the journal ... highly flexible loops in addition to the rigid domains. These are absent from the non-infectious pH 3 ... Scientists reveal the key mechanisms for affinity between transient binding proteins
... brief and occurs through a large section of the protein surface- the globular domain -, and a very small section of the surface of another proteins, the so-called lineal motif or peptide. The ... Newly described 'dragon' protein could be key to bird flu cure
... with scientists from China and Singapore, have crystallized and characterized the structure of one of the most important protein complexes of the H5N1 virus, the most common strain of bird flu.
All ... Protein misprediction uncovered by new technique
... extra-cellular parts must have a transmembrane segment. Extracellular and nuclear domains must not occur in a single protein. The number of amino acid residues in closely related members of a ... Landmark study opens door to new cancer, aging treatments
... that lives longer.
An elusive enzyme
Telomerase is a complex structure made up of multiple protein domains and a stretch of RNA, which contains the template the enzyme uses to synthesize telomeres. ... Protein found that regulates gene critical to dopamine-releasing brain cells
... . Crystal structures of the Nurr1 receptor show it to have an area where another protein could bind to it, but this "domain" is too small for usual binding partners, such as steroids.
Using a ... Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
... both surface sites and deeply buried sites within the protein require cholesterol, which directly supports contacts between the agonist-binding domain and the pores that are thought to be essential ... The structure of the Mre11 protein bound to DNA
... DNA end-structures show how the Mre11 protein has evolved to hone in on and sense these variable mutagenic ... while one part of each Mre11 protein, called the capping domain, rotates into place to adjust ... Scientists use light to control proteins
... enzyme's activity could be manipulated by shining a light on the light-sensing protein, which the scientists refer to as a "domain." "The technology works like a light switch," said Benkovic. "When ... How neuronal activity leads to Alzheimer's protein cleavage
Amyloid precursor protein (APP), whose cleavage product, amyloid-b (Ab), builds ... done to stop or reverse their formation.
APP, a protein of unknown function, is membrane associated and concentrates ...
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Carnegie Mellon scientists unveil new tool to understand evolution of multi-domain genes
... applied genes encode multi-domain proteins. Domains are sequence fragments that encode the basic ... well in verifying the ancestral patterns of multi-domain gene evolution for these families, much better ...Scientists characterize protein structure of environmentally friendly bacteria
... the U.S. Department of Energy's Argonne National Laboratory have determined the structure of a key protein domain in a bacterium that could help with bioremediation of uranium-contaminated land sites.Getting wise to the influenza virus' tricks
... publish a high-resolution image of a key protein domain whose function is to allow the virus ... messenger RNAs (mRNAs) to direct the cell's protein-synthesis machinery to the starting point. The viral ...Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
... for transforming growth factor ƒÒ and urokinase plasminogen activator. "There are quite a few other human proteins with similar predicted structures whose function is not yet known," says Lemmon. "We ...Protein linked to Alzheimer's disease also has role in HIV progression
... . Yet this seemingly small sequence difference has profound implications for the structure and function of the protein. ApoE4 has an extra intramolecular bond that results in a more compact structure, ...Tracking prions
... two different forms of a prion-forming protein domain by means of NMR spectroscopy. In the journal ... highly flexible loops in addition to the rigid domains. These are absent from the non-infectious pH 3 ...Scientists reveal the key mechanisms for affinity between transient binding proteins
... brief and occurs through a large section of the protein surface- the globular domain -, and a very small section of the surface of another proteins, the so-called lineal motif or peptide. The ...Newly described 'dragon' protein could be key to bird flu cure
... with scientists from China and Singapore, have crystallized and characterized the structure of one of the most important protein complexes of the H5N1 virus, the most common strain of bird flu. All ...Protein misprediction uncovered by new technique
... extra-cellular parts must have a transmembrane segment. Extracellular and nuclear domains must not occur in a single protein. The number of amino acid residues in closely related members of a ...Landmark study opens door to new cancer, aging treatments
... that lives longer. An elusive enzyme Telomerase is a complex structure made up of multiple protein domains and a stretch of RNA, which contains the template the enzyme uses to synthesize telomeres. ...Protein found that regulates gene critical to dopamine-releasing brain cells
... . Crystal structures of the Nurr1 receptor show it to have an area where another protein could bind to it, but this "domain" is too small for usual binding partners, such as steroids. Using a ...Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
... both surface sites and deeply buried sites within the protein require cholesterol, which directly supports contacts between the agonist-binding domain and the pores that are thought to be essential ...The structure of the Mre11 protein bound to DNA
... DNA end-structures show how the Mre11 protein has evolved to hone in on and sense these variable mutagenic ... while one part of each Mre11 protein, called the capping domain, rotates into place to adjust ...Scientists use light to control proteins
... enzyme's activity could be manipulated by shining a light on the light-sensing protein, which the scientists refer to as a "domain." "The technology works like a light switch," said Benkovic. "When ...How neuronal activity leads to Alzheimer's protein cleavage
Amyloid precursor protein (APP), whose cleavage product, amyloid-b (Ab), builds ... done to stop or reverse their formation. APP, a protein of unknown function, is membrane associated and concentrates ...