... children and seek shelter. Parents who behave as these mice do would say, 'so they get a little ... several experiments to rule out other reasons why the mutant mice were slow to retrieve pups. They ruled ...
... sleep half as much as normal mice.”
The mutant mice appeared to have a condition similar to a human ... cell membrane. The researchers genetically engineered mice to have defects in the ion channels Kv3.1 ...
... with all protein production in the cell.
McGowan, Barsh, and their colleagues found that skin from the feet of the mutant mice exhibited elevated levels of p53. This elevation, or "activation," of ...
... probable cause for hearing loss," explains senior author Professor Karen Steel. "We showed that the mutant mice carried a change in one letter of their genetic code in a gene called Atp2b2. Changing ...
... animal models for many human
genetic disorders. But there is still plenty of potential for
discovery in mice that go through spontaneous mutations: indeed,
these natural mutations can have high ...
... and molecular steps that initiate the immune defense have remained largely unknown. Using cells cultured from c-Kit mutant mice, Dr. Ray, her husband and co-corresponding author ...
... They have recently investigated the functions of one of these receptors, called ALK7, using mutant mice (knock-out mice) lacking this receptor. They found that in the absence of ALK7, mice developed ...
... models of human cancer, and colleagues developed mice with a specific mutation of p53 that mimics a common ... p53 protein.
The researchers developed p53 mutant mice that lacked one or both copies of Mdm2 ...
... (MECP2+). Previous studies had revealed only subtle differences between the brains of normal and MECP2-mutant mice, but those studies measured gene activity throughout the brain. Dr. Zoghbi's group ...
... cells, and enhanced intestinal regeneration following injury. The mutant mice thus retained better intestinal integrity and survived longer following lethal doses of radiation. ...
... speculated that disruption of normal function in the hypothalamus may underlie the obesity seen in the mutant mice, but he acknowledges that more research is needed to understand where and how this ...
... no FOXA2 in their liver cells. Compared to normal littermates, the mutant mice accumulated bile salts and failed to detoxify them properly, which resulted in liver damage. In addition, ...
... the nuage. To understand what Maelstrom does during the formation of sperm, the scientists created mutant mice that did not have the gene to produce the Maelstrom protein.
"We found that without the ...
... like responses in several behavioral paradigms, and promotes proliferation of hippocampal NPCs. Interestingly, mutant mice with abnormal BDNF exhibit anxiety-like behaviors that are not normalized by ...
... disease progression in the animals resembled the course of events in humans and may indicate that the mutant mice are useful models for studying how AML develops and testing potential therapeutics.
...
