... proteins are known to travel along double-stranded DNA, this is the first study to find a protein ... pattern "that looks like the seam on a baseball," Ha said. The DNA entry and exit points are very close ...
... areas containing single-stranded DNA, also negatively charged but to a lesser degree than double-stranded DNA, the microspheres will levitate above the substrate surface, stacking up in "equilibrium ...
... motor proteins that "rewind" sections of the double-stranded DNA molecule that become unwound, like ... prevent critical genes from being expressed. "When your DNA gets stuck in the unwound position, your ...
... life cycle of our cells, a minefield of environmental and biological assaults can lead to double-stranded DNA breaks, the most lethal and dangerous form of DNA damage. Now scientists reveal that when ...
... called histones that form structures around which DNA is "spooled" for dense packing in the cell nucleus. ... interference, or RNAi, damaged cells with double-stranded DNA breaks did not repair themselves ...
... gene and triggers a switch.
"Based on the observations we made in 2007, we predicted that doubled-stranded DNA breaks were behind the switch, but we were not able to prove it," says Dreesen, who is ...
A generation of DNA-like compounds, class R inhibitory oligonucleotides (INH-ODNs), have been shown to ... their INH-ODN drugs, composed of double-stranded DNA-like analogues carrying autoimmune-inhibitory ...
... greater access to the damage, preventing flawed DNA from being passed on as the cell divides, which causes genomic ... normal BRIT1 aids repair of double-stranded DNA breaks by allowing access to two ...
... molecules on the outside.
It's easy to explain when the cell divides because the double-stranded DNA also divides at the behest of a special enzyme, making its genetic code readily readable.
"Many ...
... scientists to cut and paste portions of double-stranded DNA, are the fundamental catalysts of molecular biology. ... natural protein-based nucleases (which cleave DNA) similarly require two metal ions," ...
... kill cancer cells by inducing double strand DNA breaks.
Because of its key roles — ... .
Adds Tainer, "Understanding how the body responds to DNA breaks is fundamental for cancer interventions and gene ...
... Pennsylvania.
The three drew on detailed molecular DNA models developed by de Pablo's research ... study the reaction pathways through which double-stranded DNA undergo denaturation, where the molecule ...
... 's toolbox, differentiates and dynamically binds both DNA and RNA as part of the virus' fierce attack on ... process RNA as well as single- or double-stranded DNA.
"Remarkably, RT can spontaneously flip ...
... because it distorts the helical structure of double-stranded DNA.
Once the damage is located, TFIIH ... bacteria use different proteins to carry out a similar DNA repair process), the gene for XPD, like ...
... somehow squeeze two meters of double-stranded DNA into the space of a typical chromosome, a package ... different way to fold large amounts of DNA into chromosomes?" Rizzo asked.
The images were produced ...
