Science news articles about 'broken chromosomes'

  • How cells handle broken chromosomes

    ... : After being recognised and initially processed by the cellular machinery, the broken chromosome is extensively scanned for homology and the break itself is later tethered to the nuclear envelope. Thus ...
  • How Cells Handle Broken Chromosomes

    ... : After being recognized and initially processed by the cellular machinery, the broken chromosome is extensively scanned for homology and the break itself is later tethered to the nuclear envelope. The researchers ...
  • Genetic 'tag team' keeps cells on cycle

    ... before it is finished copying its DNA or it will end up with broken chromosomes,” a failure with potentially devastating consequences, said Steven Haase, an assistant professor of biology at Duke ...
  • Dartmouth Medical School gene targeting discovery opens door for vaccines and drugs

    ... end joining (NHEJ), which is also used to repair DNA in broken chromosomes, and arbitrarily reinserts targeting DNA segments at incorrect locations. That makes isolating strains ...
  • Key protein aids in DNA repair

    ... of DNA – called nucleotides," he notes. Broken chromosomes can be compared to a break in a strand of yarn ... a strand of DNA, actually removes the "dirt" at broken chromosome ends, allowing for much more accurate ...
  • Worm genes KO'd

    ... " known as G, A, T and C. By "repairing" the broken chromosome, the new method can delete up to 25 ... ,000 base pairs of the location where the chromosome is broken. But that still means the method can knock ...
  • Why chromosomes never tie their shoelaces

    ... the discovery of telomeres, the protective tips of chromosomes: while broken chromosome ends generated by DNA ... while the damage is repaired. If the tips of chromosomes were recognized as broken DNA, cells would be constantly ...
  • Safeguarding genome integrity through extraordinary DNA repair

    ... divides. To prevent not only gene mutations but broken chromosomes and chromosomal abnormalities known to cause cancer, infertility, and other diseases in humans, prompt, precise ...
  • Safeguarding genome integrity through extraordinary DNA repair

    ... divides. To prevent not only gene mutations but broken chromosomes and chromosomal abnormalities known to cause cancer ... chromatids are in closest contact, which are required to transmit chromosomes from one generation to the next. Maintaining heterochromatin structure ...
  • 'Pulverized' chromosomes linked to cancer?

    ... tumors. In contrast, the mechanism by which DNA damage and broken chromosomes cause cancer is well established ... to these pulverized fragments, using an imaging trick that marked the chromosome in the micronucleus with its own color. "It has been theorized that micronuclei ...
  • To understand chromosome reshuffling, look to the genome's 3D structure

    ... thought possible. In early HTGTS studies, they found that broken chromosomes often rearrange within themselves ... in that subset, contributing to recurrent translocations." "Our finding that broken chromosome segments are more likely to join with other segments ...
  • Sending out an SOS: How telomeres incriminate cells that can't divide

    ... repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman ... proteins, who might mistake exposed chromosome ends for broken DNA. Initially, the group searched ...
  • Unusual mechanism of DNA synthesis could explain genetic mutations

    ... that involves both ends of the broken molecules. To repair a broken chromosome that lost one end, a unique ... replication, one broken end of DNA is paired with an identical DNA sequence on its partner chromosome. Replication ...

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