Researchers form new nerve cells – directly in the brain
The field of cell therapy, which aims to form new cells in the body in order to cure disease, has taken another important step in the development towards new treatments. A new report from researchers at Lund University in Sweden shows that it is possible to re-programme other cells to become nerve cells, directly in the brain. Two years ago, researchers in Lund were the first in the world to re-programme human skin cells, known as fibroblasts, to dopamine-producing nerve cells – without taking a detour via the stem cell stage. The research group has now gone a step further and shown that it is possible to re-programme both skin cells and support cells directly to nerve cells, in place in the brain.
“The findings are the first important evidence that it is possible to re-programme other cells to become nerve cells inside the brain”, said Malin Parmar, research group leader and Reader in Neurobiology.
The researchers used genes designed to be activated or de-activated using a drug. The genes were inserted into two types of human cells: fibroblasts and glia cells – support cells that are naturally present in the brain. Once the researchers had transplanted the cells into the brains of rats, the genes were activated using a drug in the animals’ drinking water. The cells then began their transformation into nerve cells.
In a separate experiment on mice, where similar genes were injected into the mice’s brains, the research group also succeeded in re-programming the mice’s own glia cells to become nerve cells.
“The research findings have the potential to open the way for alternatives to cell transplants in the future, which would remove previous obstacles to research, such as the difficulty of getting the brain to accept foreign cells, and the risk of tumour development”, said Malin Parmar.
All in all, the new technique of direct re-programming in the brain could open up new possibilities to more effectively replace dying brain cells in conditions such as Parkinson’s disease.
“We are now developing the technique so that it can be used to create new nerve cells that replace the function of damaged cells. Being able to carry out the re-programming in vivo makes it possible to imagine a future in which we form new cells directly in the human brain, without taking a detour via cell cultures and transplants”, concluded Malin Parmar.
Source: Lund University
- Scientists form new nerve cells – directly in the brainfrom Science DailyTue, 26 Mar 2013, 11:30:29 EDT
- Researchers form new nerve cells – directly in the brainfrom Science BlogTue, 26 Mar 2013, 10:00:25 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Caltech chemists solve major piece of cellular mystery
- Future climate models greatly affected by fungi and bacteria
- Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells
- Moffitt makes important steps toward developing a blood test to catch pancreatic cancer early
- Sir Elton John is the inspiration behind the name of a new coral reef crustacean species
- Rare nautilus sighted for the first time in 3 decades
- Want a better relationship and a better sex life?
- Unlike boys, girls lose friends for having sex, gain friends for making out
- Massive study reports challenges in reproducing published psychology findings
- Record-high pressure reveals secrets of matter
- Gravitational constant appears universally constant, pulsar study suggests
- Robotic insect mimics Nature's extreme moves
- California 'rain debt' equal to average full year of precipitation
- Special issue: Philae results shed light on the nature of comets
- Researchers find that Earth's magnetic shield is much older than previously thought