New animal study shows promise for development of Parkinson's disease drug
Few treatments for Parkinson's disease (PD) restore function for extended periods. In a new study published today in the inaugural issue issue of the Journal of Parkinson's Disease, an international group of researchers report that platelet-derived growth factor-BB (PDGF-BB) restored function in rodents and shows promise as a clinical candidate drug for treatment of PD. Parkinson's disease is the second most common neurodegenerative disorder, affecting 1% of the population over the age of 65. It is characterized by loss of brain cells (neurons) from the mid-brain which use the neurotransmitter dopamine to help control voluntary movements. Investigators from NeuroNova AB, Stockholm, Sweden, the Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, The Parkinson's Institute, Sunnyvale, CA, USA, and Motac Neuroscience Ltd, Manchester, UK, found that behavioral, tissue and biochemical changes in experimental models of Parkinson's disease in rodents could be counteracted by infusion of PDGF-BB. This could offer an alternative strategy to restore function in PD.
"In animal models of nigrostriatal injury, a two weeks treatment with platelet-derived growth factor-BB resulted in long-lasting restoration of striatal dopamine transporter binding sites and expression of nigral tyrosine hydroxylase," commented Anders Haegerstrand, MD, PhD, Chief Scientific Officer, NeuroNova AB, Stockholm, Sweden."It also normalized amphetamine-induced rotational behavior in 6-hydroxydopamine lesioned rats. Platelet-derived growth factor-BB promoted proliferation of neural progenitor cells in the subventricular zone. The effects on dopaminergic neurons and functional recovery could be blocked by co-infusion with a proliferation inhibitor, indicating a link between the proliferative and anti-parkinsonian effects. Based on the current data, we consider platelet-derived growth factor-BB a clinical candidate drug for treatment of Parkinson's disease."
Source: IOS Press
Articles on the same topic
- New method for measuring Parkinson's disease prevalence reveals sharp increase in IsraelThu, 9 Jun 2011, 12:09:56 EDT
- Landmark study analyzes scientific productivity and impact of the top 100 PD investigators Thu, 9 Jun 2011, 12:09:48 EDT
- New animal study shows promise for development of Parkinson's disease drugfrom Science DailyFri, 10 Jun 2011, 9:30:16 EDT
- New method for measuring Parkinson's disease prevalence reveals sharp increase in Israelfrom Science DailyFri, 10 Jun 2011, 9:30:14 EDT
- Landmark study analyzes scientific productivity and impact of the top 100 PD investigatorsfrom PhysorgThu, 9 Jun 2011, 13:30:36 EDT
- New animal study shows promise for development of Parkinson's disease drugfrom PhysorgThu, 9 Jun 2011, 12:02:20 EDT
- New method for measuring Parkinson's disease prevalence reveals sharp increase in Israelfrom PhysorgThu, 9 Jun 2011, 12:02:13 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
No popular news yet
- University of Tennessee study finds crocodiles climb trees
- AGU: A 'shark's eye' view: Witnessing the life of a top predator
- New dinosaur found in Portugal, largest terrestrial predator from Europe
- WASP gives NASA's planetary scientists new observation platform
- Scientists identify gene linking brain structure to intelligence