A stem cell secreted protein can be given to improve heart function after experimental heart attack
Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair. Giving the right dose of this protein named secreted frizzled related protein 2 (sfrp2) in studies of rats helped to prevent heart failure and reduce collagen layering that can form thick scar tissue after a heart attack (also called MI, or myocardial infarction). Previously the same researchers demonstrated that this protein also saves heart muscle cells from dying in response to heart attack. These findings have the potential to be translated into a new therapy for study and evaluation in human clinical trials, said Victor Dzau, M.D., senior author of the study and James B Duke Professor of Medicine.
"We found that giving the study rats the protein sfrp2 strongly improved heart function in the critical pumping chamber, the left ventricle, after a myocardial infarction," Dr. Dzau said. "We observed that sfrp2 at therapeutic doses reduced heart muscle death and also directly prevented deposits of collagen, and thus reduced the scarring that can affect heart function."
The study was published the week of Nov. 15 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition online.
Giving sfrp2 also helped prevent the heart wall from thinning, by the fourth week after injection. Because the scarring process (fibrosis) and tissue remodeling in the heart are often complete within a month of a heart attack in rats, the team performed a heart test called echocardiography (heart ultrasound) on the rats at three and four weeks after the myocardial infarction.
"We found the sfrp2 reduced the area of fibrosis in the left ventricle and also significantly decreased the ratio of anterior-to-posterior wall thickness in the heart," said Maria Mirotsou, Ph.D., a co-author and assistant professor of medicine.
Previously, the Dzau laboratory showed that a genetically modified type of stem cell that over-produced a factor called Akt dramatically reduced the size of the area affected by a heart attack and restored cardiac function in rodent hearts. The team identified sfrp2 as a key factor released by these stem cells during heart tissue survival and repair, and this study showed sfrp2 was a likely candidate for inhibiting collagen production, as well.
Source: Duke University Medical Center
- Reducing the damage of a heart attackMon, 15 Dec 2008, 13:15:15 EST
- Protein could be new target to reduce damage after heart attackThu, 24 Feb 2011, 16:39:12 EST
- First-of-its-kind stem cell study re-grows healthy heart muscle in heart attack patientsMon, 13 Feb 2012, 23:33:38 EST
- Preventing a broken heart: Research aims to reduce scarring from heart attacksSun, 14 Dec 2008, 13:22:39 EST
- Scientists turn patients' skin cells into heart muscle cells to repair their damaged heartsTue, 22 May 2012, 21:31:55 EDT
Articles on the same topic
- Aged, damaged hearts yield stem cells that could treat heart failureWed, 17 Nov 2010, 11:08:39 EST
- Treating heart attack with fat-derived stem cells may be safe in humansTue, 16 Nov 2010, 11:04:44 EST
- Stem cell patch may result in improved function following heart attackMon, 15 Nov 2010, 17:06:06 EST
- Aged, damaged hearts yield stem cells that could treat heart failure, research suggestsfrom Science DailySun, 21 Nov 2010, 11:30:33 EST
- Stem cell-secreted protein can be given to improve heart function after experimental heart attackfrom Science DailyThu, 18 Nov 2010, 19:31:11 EST
- A stem cell secreted protein can be given to improve heart function after experimental heart attackfrom Science CentricThu, 18 Nov 2010, 6:20:39 EST
- A stem cell secreted protein can be given to improve heart function after experimental heart attackfrom Science BlogWed, 17 Nov 2010, 18:30:47 EST
- Stem cell secreted protein can be given to reduce scarring and improve heart functionfrom PhysorgWed, 17 Nov 2010, 15:52:12 EST
- Aged, damaged hearts yield stem cells that could treat heart failurefrom PhysorgWed, 17 Nov 2010, 11:00:38 EST
- Treating heart attack with fat-derived stem cells may be safe in humansfrom PhysorgTue, 16 Nov 2010, 12:31:22 EST
- Treating heart attack with fat-derived stem cells may be safe in humansfrom Science DailyTue, 16 Nov 2010, 12:31:01 EST
- Stem cell patch may result in improved function following heart attackfrom Science DailyTue, 16 Nov 2010, 4:20:44 EST
- Stem cell patch may result in improved function following heart attackfrom PhysorgMon, 15 Nov 2010, 17:30:56 EST
- Stem cell patch may result in improved function following heart attackfrom Science BlogMon, 15 Nov 2010, 17:00:43 EST
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
No popular news yet
No popular news yet
- Stem cell transplant restores memory, learning in mice
- 2 landmark studies report on success of using image-guided brachytherapy to treat cervical cancer
- Calculating tsunami risk for the US East Coast
- Researchers discover mushrooms can provide as much vitamin D as supplements
- Cutting back on sleep harms blood vessel function and breathing control