'Firefly' stem cells may help repair damaged hearts
Stem cells that glow like fireflies could someday help doctors heal damaged hearts without cutting into patients' chests. In his University of Central Florida lab, Steven Ebert engineered stem cells with the same enzyme that makes fireflies glow. The "firefly" stem cells glow brighter and brighter as they develop into healthy heart muscle, allowing doctors to track whether and where the stem cells are working.
Researchers are keenly interested in stem cells because they typically morph into the organs where they are transplanted. But why and how fast they do it is still a mystery. Now Ebert's cells give researchers the ability to see the cells in action with the use of a special camera lens that picks up the glow under a microscope.
"The question that we answered was, 'How do you follow these cells in the lab and find out where they're going?'" said Ebert, an associate professor in UCF's College of Medicine.
If doctors can figure out exactly how the cells repair and regenerate cardiac tissue, stem cell therapies could offer hope to more than 17.6 million Americans who suffer from coronary disease. The glow of the enzyme also means therapies would no longer require cutting into patients' chest cavities to monitor the healing.
The study, funded by the National Institutes of Health and the American Heart Association, is a featured cover story in this month's highly ranked Stem Cell and Development Journal. (http://www.liebertonline.com/doi/abs/10.1089/scd.2009.0308?prevSearch=allfield%253A%2528Ebert%2529&searchHistoryKey= )
Now that scientists can track the stem cells, Ebert said he hopes to use them in disease models to determine how they heal a damaged heart and what conditions are most suitable for the stems cells to thrive.
Source: University of Central Florida
- 'Firefly' stem cells may help repair damaged heartsfrom Biology News NetWed, 29 Sep 2010, 0:49:09 EDT
- 'Firefly' stem cells may help repair damaged heartsfrom Science DailyTue, 28 Sep 2010, 15:28:21 EDT
- 'Firefly' stem cells may help repair damaged heartsfrom PhysorgTue, 28 Sep 2010, 13:14:31 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Hubble finds 3 surprisingly dry exoplanets
- Earlier Stone Age artifacts found in Northern Cape of South Africa
- No returning to Eden: Researchers explore how to restore species in a changing world
- Newly discovered gut virus lives in half the world's population
- Election surprises tend to erode trust in government
- Mysterious dance of dwarfs may force a cosmic rethink
- Speedy computation enables scientists to reconstruct an animal's development cell by cell
- Genetic risk for autism stems mostly from common genes
- Global warming 'pause' since 1998 reflects natural fluctuation
- Mammoth and mastodon behavior was less roam, more stay at home
- Smithsonian scientist and collaborators revise timeline of human origins
- Chimps like listening to music with a different beat, research finds
- Meet the gomphothere: UA archaeologist involved in discovery of bones of elephant ancestor
- New view of Rainier's volcanic plumbing
- Domestication syndrome: White patches, baby faces and tameness