Total fat, trans fat linked to higher incidence of ischemic stroke
Post-menopausal women who reported consuming the most daily dietary fat had a 40 percent higher incidence of clot-caused strokes compared to women who ate the least amount, according to research presented at the American Stroke Association's International Stroke Conference 2010. The incidence of ischemic stroke also increased by 30 percent in the quartile of women consuming the highest daily amount of trans fat (average intake 7 grams per day) compared to those who consumed the least (average 1 gram/day). Two common sources of trans fat are processed foods and fried foods.
Ischemic strokes are caused by blockages in blood vessels in or leading to the brain.
"We found positive associations between total fat intake and ischemic stroke incidence and between trans fat intake and ischemic stroke incidence," said Sirin Yaemsiri, M.S.P.H., a doctoral student in the department of epidemiology in the Gillings School of Global Public Health at the University of North Carolina in Chapel Hill.
The study is the first to examine the associations of different fats and different subtypes of ischemic stroke in post-menopausal women, who face a higher stroke risk than men of a similar age.
Evidence from other studies shows that different types of fat have different effects on the incidence of coronary heart disease (CHD), with trans fat implicated in the development of CHD. However, studies of ischemic stroke and fat have been inconclusive, possibly because earlier studies had small numbers of ischemic stroke cases.
Before menopause, women have a lower risk of stroke compared to men of similar age, a situation that reverses after menopause, Yaemsiri said.
The analysis included data on 87,230 post-menopausal women ages 50 to 79 who participated in the Women's Health Initiative (WHI) Observational Study, a project sponsored by the National Institutes of Health and the National Heart, Lung and Blood Institute. The women answered a food frequency questionnaire when they entered the study and were followed for an average of 7.6 years, the researchers said. During that time, 1,049 ischemic strokes occurred.
Researchers looked for links between dietary fat intake and four ischemic stroke subtypes, which were characterized by their size or point of origin. However, the data on ischemic stroke subtypes fell short of statistical significance, perhaps because strokes are difficult to characterize and 43 percent (445 cases) of the ischemic strokes in the study were of unknown type, Yaemsiri said.
Researchers divided the women into quartiles based on the amount of total dietary fat and types of fat (saturated fat, monounsaturated fat, polyunsaturated fat and trans fat) they reported consuming per day.
Variables included age, race, smoking status, physical activity, alcohol or aspirin use, body mass index, hormone therapy, heart disease history, diabetes, systolic blood pressure and whether the women took medication for high blood pressure or to reduce cholesterol, vitamin E supplementation, fruit/vegetable intake, total calories and dietary fiber.
Women in the top quartile for total fat intake had an average intake of 86 grams of total fat per day. Those in the lowest quartile consumed an average of 26 grams a day.
"I think our findings support the American Heart Association recommendations for keeping trans fat intake at less than 1 percent of energy," said Ka He, M.D., Sc.D., M.P.H., senior author of the study and associate professor of nutrition and epidemiology at the UNC Gillings School of Global Public Health.
Trans fats can be found in many foods – especially in fried foods like french fries and doughnuts, and baked goods including pastries, pie crusts, biscuits, pizza dough, cookies, crackers and stick margarines and shortenings.
Source: American Heart Association
Articles on the same topic
- UAB study shows African-Americans have highest stroke rate, southerners more likely to dieFri, 26 Feb 2010, 21:42:09 UTC
- Blacks more likely to have undiagnosed key stroke risk factor, have higher stroke incidenceFri, 26 Feb 2010, 15:10:49 UTC
- Children can have recurrent strokesWed, 24 Feb 2010, 23:04:12 UTC
- Stroke incidence rising among younger adults, decreasing among elderlyWed, 24 Feb 2010, 22:41:19 UTC
- Clot-busting drugs effective in patients with unwitnessed strokesWed, 24 Feb 2010, 18:59:02 UTC
- Half of Americans live more than an hour away from lifesaving stroke careWed, 24 Feb 2010, 16:14:35 UTC
- Decade of efforts in stroke documented in new reportWed, 24 Feb 2010, 15:35:12 UTC
- Deficits in brain's 'executive' skills common with TIA, minor strokeWed, 24 Feb 2010, 15:35:06 UTC
- Indiana U. researcher, hospital, study potential rehab following 'mini stroke'Wed, 24 Feb 2010, 15:34:58 UTC
Other sources
- Stroke incidence rising among younger adults, decreasing among elderlyfrom Science DailyMon, 1 Mar 2010, 3:28:17 UTC
- UAB study shows African-Americans have highest stroke rate, southerners more likely to diefrom Science BlogSat, 27 Feb 2010, 22:35:30 UTC
- African-Americans have highest stroke rate, southerners more likely to die, study findsfrom Science DailySat, 27 Feb 2010, 2:42:10 UTC
- UAB study shows African-Americans have highest stroke rate, southerners more likely to diefrom Science BlogSat, 27 Feb 2010, 0:07:12 UTC
- Blacks more likely to have undiagnosed key stroke risk factor, have higher stroke incidencefrom PhysorgFri, 26 Feb 2010, 18:07:26 UTC
- Blacks more likely to have undiagnosed key stroke risk factor, have higher stroke incidencefrom Science BlogFri, 26 Feb 2010, 15:35:19 UTC
- Total fat, trans fat linked to higher incidence of ischemic strokefrom Science DailyThu, 25 Feb 2010, 4:14:54 UTC
- Clot-busting drugs effective in patients with unwitnessed strokesfrom Science DailyThu, 25 Feb 2010, 4:14:35 UTC
- Children can have recurrent strokesfrom Science DailyThu, 25 Feb 2010, 4:14:13 UTC
- Children can have recurrent strokesfrom PhysorgWed, 24 Feb 2010, 23:42:15 UTC
- Children can have recurrent strokesfrom Science BlogWed, 24 Feb 2010, 23:14:15 UTC
- Stroke incidence rising among younger adults, decreasing among elderlyfrom PhysorgWed, 24 Feb 2010, 22:35:29 UTC
- Total fat, trans fat linked to higher incidence of ischemic strokefrom PhysorgWed, 24 Feb 2010, 22:35:27 UTC
- Clot-busting drugs effective in patients with unwitnessed strokesfrom PhysorgWed, 24 Feb 2010, 18:43:51 UTC
- Half of Americans live more than an hour away from lifesaving stroke carefrom PhysorgWed, 24 Feb 2010, 17:49:19 UTC
- Half of Americans live more than an hour away from lifesaving stroke carefrom Science BlogWed, 24 Feb 2010, 16:49:45 UTC
- Researchers study potential rehab following 'mini stroke'from PhysorgWed, 24 Feb 2010, 16:21:29 UTC
- Decade of efforts in stroke documented in new reportfrom PhysorgWed, 24 Feb 2010, 15:56:39 UTC
- Deficits in brain's 'executive' skills common with TIA, minor strokefrom PhysorgWed, 24 Feb 2010, 15:28:22 UTC
- SongTherapy Aiding Stroke Patientsfrom CBSNews - ScienceTue, 23 Feb 2010, 19:28:31 UTC