The hepatitis healing power of blueberry leaves
A chemical found in blueberry leaves has shown a strong effect in blocking the replication of the Hepatitis C virus, opening up a new avenue for treating chronic HCV infections, which affect 200 million people worldwide and can eventually lead to cirrhosis and liver cancer. Among the areas of especially high Hepatitis C incidence is the Miyazaki prefecture of southern Japan, a trend that led Hiroaki Kataoka and colleagues at the University of Miyazaki and elsewhere in Japan on a search for better treatment options. Currently, there is no vaccine for HCV, and though a combination drug regimen can clear HCV infection, this treatment is only about 60% effective on average and poses risks of severe side effects.
Kataoka and colleagues believed that since HCV is localized in the liver and can take 20 years or more to develop into disease, a dietary supplement might help slow or stop disease progression. So they screened nearly 300 different agricultural products for potential compounds that suppress HCV replication and uncovered a strong candidate in the leaves of rabbit-eye blueberry (native to the southeastern US).
They purified the compound and identified it as proanthocyandin (a polyphenol similar to the beneficial chemicals found in grapes and wine). While proanthocyandin can be harmful, Kataoka and colleagues noted its effective concentration against HCV was 100 times less than the toxic threshold, and similar chemicals are found in many edible plants, suggesting it should be safe as a dietary supplement. In the meantime, the researchers now hope to explore the detailed mechanisms of how this chemical stops HCV replication.
Articles on the same topic
- Current hepatitis C treatments work equally well, UT Southwestern and national researchers reportFri, 7 Aug 2009, 10:09:16 EDT
- The hepatitis healing power of blueberry leavesfrom Science CentricSat, 8 Aug 2009, 12:49:07 EDT
- Current hepatitis C treatments work equally wellfrom Science CentricSat, 8 Aug 2009, 11:42:15 EDT
- The hepatitis healing power of blueberry leavesfrom Biology News NetFri, 7 Aug 2009, 18:42:15 EDT
- Hepatitis Healing Power Of Blueberry Leavesfrom Science DailyFri, 7 Aug 2009, 13:21:05 EDT
- The hepatitis healing power of blueberry leavesfrom PhysorgFri, 7 Aug 2009, 11:56:24 EDT
- Current hepatitis C treatments work equally well, researchers reportfrom PhysorgFri, 7 Aug 2009, 10:07:28 EDT
- Current hepatitis C treatments work equally well, UT Southwestern and national researchers reportfrom Science BlogFri, 7 Aug 2009, 10:07:16 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Genomic info may help researchers fathom bedbug insecticide resistance
- Hepatitis virus-like particles as potential cancer treatment
- Lithium battery catalyst found to harm key soil microorganism
- Turbulent times: When stars approach
- New tarantula named after Johnny Cash among 14 spider species found in the United States
- Genome of the flowering plant that returned to the sea
- Researchers' preclinical trial upends conventional wisdom about responses to fear
- Reconfigurable origami tubes could find antenna, microfluidic uses
- Scientists build a neural network using plastic memristors
- How 'more food per field' could help save our wild spaces